Cytochemistry of Acute Promyelocytic Leukemia ( M 3 ) :

نویسندگان

  • Masao Tomonaga
  • Yoshiharu Yoshida
  • Masuko Tagawa
  • Itsuro Jinnai
  • Kazutaka Kuriyama
  • Tatsuhiko Amenomori
  • Akira Yoshioka
  • Tatsuki Matsuo
  • Hiroaki Nonaka
  • Michito Ichimaru
چکیده

Cytochemical investigation of leukemic promyelocytes from 25 cases of acute promyelocytic leukemia (M3) disclosed two major cellular differentiation categories: (1 ) the pure neutrophilic (N) type (1 6 cases) with strong myeloperoxidase (MPO) and naphthol-ASD chloroacetate esterase (Es-chl), but lacking the monocytic enzyme NaF-sensitive alpha-naphthyl butyrate esterase (Es-b). and (2) the mixed neutrophilic/monocytoid (N/M) type (seven cases) with strong Es-b as well as strong MPO. all cases exhibiting Es-dual (Es-b + Es-chl) positive cells. Two more cases with unusual phenotypes were noted: one with intense lysozyme activity but without Es-b and the other with toluidine blue-methachromasia and negative MPO. Promyelocytes from the control group, consisting of nine cases of t(8;21) M2 AML and ten cases with normal bone marrow, lacked

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تاریخ انتشار 2005